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Clinical,Radiological,Neurophysiological,and Neuropathological Characteristics of Gluten Ataxia Lancet 352:1582-1585, Hadjivassiliou,M.,et al, 1998 See this aricle in Pubmed Article Abstract 28 patients with gluten ataxia were identified. All had gait ataxia and most had limb ataxia. Those with more severe gait ataxia had longer disease duration. No patient had tremor or other extrapyramidal features. 19 patients showed some form of peripheral neuropathy on neurophysiological examination. 16 patients had no gastrointestinal symptoms. Distal duodenal biopsy showed lymphocytic infiltration in two patients, and changes compatible with coeliac disease in 11. Six patients had evidence of cerebellar atrophy on magnetic resonance imaging. Necropsy was done on two patients who died; there was lymphocytic infiltration of the cerebellum, damage to the posterior columns of the spinal cord, and sparse infiltration of the peripheral nerves. Gluten sensitivity is an important cause of apparently idiopathic ataxia and may be progressive. The ataxia is a result of immunological damage to the cerebellum, to the posterior columns of the spinal cord, and to peripheral nerves. We propose the term gluten ataxia to describe this disorder.

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(click to filter results - removes previous filter) ataxia ataxic gait celiac disease,adult cerebellar atrophy,secondary cerebellar degeneration cerebral cortical atrophy gait disorder gliadin antibodies gluten sensitivity intestinal biopsy MRI MRI,abnormal neuropathology neuropathy Purkinje cell serologic testing

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